Curcumin (diferuloylmethane), a polyphenol, is an active principle of the perennial herb Curcuma longa (commonly known as turmeric). Curcumin possesses various medicinal properties. Despite curcumin’s multiple medicinal benefits, low oral bioavailability of curcumin continues to be highlighted as a major problem. Curcumin is safe and beneficial in several aliments was formulated into biodegradable microspheres with view to improve its oral bioavailability. Curcumin encapsulated microspheres prepared by coacervation-emulsification method were spherical in shape with particle size in range 0 to 30 µm and 72.97% entrapment at 58.72 loading. The curcumin encapsulated microspheres were able to withstand the International Conference on Harmonisation (ICH) accelerated stability test conditions for the studied duration of 3 months. XRD studies showed that the nature of pure drug curcumin remain unaffected till the completion of process of microspheres formation which was also supported by DSC results. In vitro release was predominantly by diffusion phenomenon and follows first order release pattern. The results clearly indicate the promise of microspheres for oral delivery of poorly bioavailable molecules like Curcumin.
Loading....